Veterinarians

The active ingredients in Chocolate Rescue immediately and permanently bind the methylxanthines caffeine and theobromine before they're able to poison a dog.

Chocolate Rescue is very safe. All of the ingredients are General Regarded as Safe (GRAS) by the FDA. The product has shown no adverse side effects in mice and dogs.

Chocolate Rescue is extremely effective in permanently encapsulating caffeine and theobromine. The product uses a specially-formulated combination of ingredients that instantly draws the free toxins out of the chyme before they can be absorbed. Further, there are millions of binding sites in each dose of Chocolate Rescue, meaning that one chew will effectively nullify large quantities of high-concentration chocolate in a dog's stomach.

Administering activated charcoal has downsides and potential adverse reactions. As a general absorption product, a large volume is needed to absorb everything in an animal's stomach in order to bind the toxins. Aspirational pneumonia, intestinal blockages, and potential difficulty force-feeding an unwilling dog are all drawbacks to activated charcoal.

Chocolate Rescue addresses these drawbacks. The active ingredients quickly push away saliva and other non-toxic molecules, targeting only theobromine and caffeine, allowing a much smaller dose to bind the toxins. As a result, there exists no risk of aspirational pneumonia or intestinal blockage. Most notably, dogs will eat the palatable treat willingly, and at only 7 grams, even a dog with a little appetite can easily be given the potentially life-saving "treat."

The chew should be given as soon as possible, ideally within 1 hour after chocolate consumption. The harmful molecules are rapidly absorbed in the stomach, and 99% of the absorption occurs within 45 minutes of ingestion on an empty stomach. The presence of other materials in a dog's stomach will slow toxin absorption and increase the window of treatment effectiveness.

Tawde SN, Puschner B, Albin T, Stump S, Poppenga RH. Death by caffeine: presumptive malicious poisoning of a dog by incorporation in ground meat. J Med Toxicol. 2012 Dec;8(4):436-40. doi: 10.1007/s13181-012-0254-y. PMID: 23104127; PMCID: PMC3550263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550263/#!po=4.68750

C. Weingart, A. Hartmann, B. Kohn. Chocolate ingestion in dogs: 156 events (2015–2019). Retrospective evaluation of clinical signs, clinical pathological findings, therapy and outcome of 156 dogs after chocolate ingestion. The concentration of methylxanthines (theobromine, caffeine) was calculated based on the type of chocolate and the amount ingested. Volume 62, Issue11. November 2021
Pages 979-983. https://onlinelibrary.wiley.com/doi/full/10.1111/jsap.13329

Wink, Michael. (2016). Alkaloids: Toxicology and Health Effects. Encyclopedia of Food and Health. 10.1016/B978-0-12-384947-2.00020-9. Alkaloids are produced by many plants as defense chemicals not only mainly against herbivores but also against microbial pathogens. Many alkaloids exhibit a pronounced toxicity in animal models and humans. A major target in animals is the nervous system and many alkaloids structurally resemble neurotransmitters. Because of structural similarity, they can interfere with neurotransmitter receptors or ion channels and thus modulate neuronal signal transduction. Also, other organs can be affected by toxic alkaloids, such as the liver, kidneys, heart and circulation, gastrointestinal tract, and reproductive organs. At a molecular level, alkaloids can interfere with membrane permeability, membrane proteins (ion channels and receptors), enzymes and other proteins, DNA, RNA and corresponding proteins, electron chain, and the cytoskeleton. Because of these pharmacological properties, some alkaloids can be used in medicine to treat infections, health disorders, and even cancer.

Jadhav¹, Rushikesh & Ghorpade², Trupti & Waghmare³, Santosh & Andhale⁴, Ashwini & Kamble⁵, Hemant & Mca, Shivam. (2021). The Pharmacological Action of Common Ayurvedic Drugs. SSRN Electronic Journal. 8. e65-e76. A solitary traditional medication by and large has one predominant pharmacological method of activity which represents its restorative viability, though a home grown cure on account of the different dynamic specialists it contains, for the most part impacts a few biochemical and additionally physiological frameworks present in the body.It analyzes a significant class of sub positions, the adaptogens, and the different synthetic structures it embraces, like the saponins and triterpenes. The Herbs with adjust the invulnerable framework, for example garlic, turmeric and St John's Wort, are moreover reviewed, just like the alkaloids and organic calming specialists. Herbs which apply pharmacological activity by means of their nitric oxide administrative properties are recorded, similar to those which give fundamental miniature supplements, like nutrients and certain minerals. The survey closes with remark on the significance of understanding home grown cure methods of activity as a positive advance to their more extensive reception in the cutting edge restorative armamentarium.

Gans, J.H., Korson, R., Cater, M.R. & Ackerly, C.C. (1980) Effects of short-term and long-term theobromine administration to male dogs. Toxicol. appl. Phannacol., 53, 481-496

Rosenkranz, H.S. & Ennever, F.K. (1987b) Evaluation of the genotoxicity of theobromine and caffeine. Food chem. Toncol., 25, 247-251

Finlay F, Guiton S. Chocolate poisoning. BMJ. 2005 Sep 17;331(7517):633. PMCID: PMC1215566.

Alridge, Andrew. The Effect of Age and Species on the Metabolism of Caffeine. 1979.

https://www.clinicaltrials.gov/ct2/show/NCT04607018 The ion-loaded natural PMA-zeolite do not act on the body as ion-robber in the digestive tract. The naturally occurring zeolites absorb defined ions in accordance to their selectivity alignment from their surroundings - e.g. in the gastrointestinal tract in the case of the specific certified PMA-zeolite. At the same time the PMA-zeolite absorbs defined harmful substances (mainly heavy metals and ammonium ions) in the gastrointestinal tract, while at the same time the alkaline ions contained in the crystal lattice are released (Mg2+, Ca2+, K+, Na+). Loaded with harmful substances, the zeolite is then excreted through the gastrointestinal tract without interfering with the body's metabolism.

Sherman, John D., PNAS. March 30, 1999 96(7)3471-3478 https://www.pnas.org/doi/10.1073/pnas.96.7.3471

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